Product Description

The Fourth Edition of Greene′s Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998, including...

• New protective groups such as the fluorous family and the uniquely removable 2–methoxybenzenesulfonyl group for the protection of amines
• New techniques for the formation and cleavage of existing protective groups, with examples to illustrate each new technique
• Expanded coverage of the unexpected side reactions that occur with protective groups
• New chart covering the selective deprotection of silyl ethers
• 3,100 new references from the professional literature

The content is organized around the functional group to be protected, and ranges from the simplest to the most complex and highly specialized protective groups.

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Product Details

• Amazon Sales Rank: #523238 in Books
• Published on: 2006-12-08
• Original language: English
• Number of items: 1
• Binding: Hardcover
• 1110 pages

Review
"An essential bible for the library or personal bookshelf of chemists performing complex synthesis." (CHOICE, May 2007)

"...the most up–to–date compilation available...should be an integral part of all institutional libraries...it is also highly recommended that individuals...maintain their own copy..." (Journal of Medicinal Chemistry, March 8, 2007)

"...continues to be a comprehensive guide to the techniques for the formation and cleavage of protective groups." (Journal of the American Chemical Society, January 31, 2007)

Review
"An essential bible for the library or personal bookshelf of chemists performing complex synthesis." (CHOICE, May 2007)

"...the most up–to–date compilation available...should be an integral part of all institutional libraries...it is also highly recommended that individuals...maintain their own copy..." (Journal of Medicinal Chemistry, March 8, 2007)

"...continues to be a comprehensive guide to the techniques for the formation and cleavage of protective groups." (Journal of the American Chemical Society, January 31, 2007)

From the Back Cover
The Most Comprehensive Guide to Protective Groups in Organic Synthesis Currently Available

For more than twenty–five years, Protective Groups in Organic Synthesis has been the definitive guide for organic chemists in designing synthetic routes. Now in its fourth edition, the text continues to be a uniquely comprehensive and an indispensable reference for both synthetic organic and medicinal chemists who want to control the reactivity of the most common functional groups during a synthetic sequence.

The Fourth Edition includes significant developments in protective group chemistry since 1998. In addition to incorporating new protective groups now available to the synthetic organic chemist, such as the uniquely removable 2–methoxybenzenesulfonyl group for the protection of amines, the book also covers new techniques for the formation and cleavage of existing protective groups, providing the most relevant and useful examples to illustrate each methodology. The content is organized around the functional group to be protected (ethers, acids, carbonyl groups, amines, amides, phenols, etc.), and ranges from the simplest to the most complex highly specialized protective groups.

New features of the Fourth Edition include:

• The addition of numerous new protective groups, such as the fluorous family
• New methods for the cleavage and introduction of many of the classic protective groups highlighting selectivity issues when reported in the literature
• Expanded coverage of the unexpected side reactions that occur with protective groups
• A new chart covering the selective deprotection of silyl ethers
• 3,100 new references from the professional literature, complete through the end of 2005

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Customer Reviews

An Organic Chemists Bible
This book is a must have, for undertaking synthetic organic research. The extensive lists of common and unusual methods and the tables of reactivity make it a worthwhile investment.

It'll save you its price in chemicals in weeks, by providing tried and tested methods.

Indispensible
As an organic chemistry graduate student, I am constantly fighting to get my hands on either of the two copies in our lab. Greene has written an extensive and in-depth book that allows easy access to information and original literaute sources. The compatibility chart at the back is great.