Product Description

What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes. But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism. The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out the systems biology view of life.

Product Details

• Amazon Sales Rank: #214078 in Books
• Published on: 2006-06-08
• Original language: English
• Number of items: 1
• Binding: Hardcover
• 176 pages

Guardian, 8 July 2006
highly evocative essay

Review
An excellent informal introduction to the concepts and issues that form the bedrock of systems biology... His conversational style gives readers the feeling they are with him sharing in an active process of discovery. (Eric Werner, Science )

highly evocative essay (Steven Poole, Guardian )

About the Author
Denis Noble, CBE, FRS, is Professor of Cardiovascular Physiology at the University of Oxford and is widely regarded as one of the popular proponents (and a very early founder of) of systems biology. He was Chairman of the IUPS World Congress in 1993, and Secretary-General of IUPS from 1993-2001. He played a major role in launching the Physiome Project, one of the international components of the systems biology approach, and Science included him amongst its review authors for its
issue devoted to the subject in 2002.

His previous publications include the seminal set of essays The Logic of Life (Boyd and Noble, OUP 1993), and he frequently appears in newspapers, and on TV and radio.

Customer Reviews

Entertaining and thought-provoking
I endorse Lars Petter Endresen's views whole-heartedly. The book is a brain-stretching delight: an impassioned attack on narrow thinking regarding evolution, whether from the general media or other, specialised scientists. There is a parallel with Damasio's "Descartes' Error", in that the author builds a clear and compelling argument for whole, integrated body systems being created through complexity, but whereas Damasio painstakingly builds the science, Noble charges through the book, scattering entertaining anecdotes, analogies and even Buddhist fables. Magnificent.

One of the most important books I have ever read.
I honestly really enjoyed reading the book "The Music of Life" - it is one of the most important books I have ever read. Denis Noble's analogy between life and music is an important one. Just as music cannot be understood by investigating single notes at a time, one cannot investigate life by looking at single genes only. The interplay between genes, between genes and proteins, and between proteins is just as important as the genes themselves.

What makes this book particularly interesting is the combination of state of the art knowledge in many totally different fields - it is rare to find a book with so many well founded and important philosophical implications of the scientific discoveries in our time. I had to read this book twice to really appreciate all the beautiful metaphors, and I would recommend this book to everybody that enjoyed Erwin Schrödinger's book "What is Life?" - this book is an update.

Small in size; big on ideas
Denis Noble describes his short book, "The Music of Life: Biology Beyond Genes", as a polemic. It is, in fact, a clarion call for a rethink to the reductionist dogmas that currently plague--and hinder--so much scientific thinking, particularly in the field of biology and, most especially, genetics. Professor Noble is not, of course, alone in making this call (see, for instance, Stuart Kaufmann's "Reinventing the Sacred" or "Evolution in Four Dimensions" by Eva Jablonka and Marion J. Lamb) but he presents a particularly clear-sighted argument which few others have so far matched. His is a far-reaching and eminently readable disquisition, attacking first the popular metaphor articulated primarily by Richard Dawkins in "The Selfish Gene" (and promulgated endlessly--usually incorrectly--by science popularists ever since) that genes are the engines of evolution and each genome a comprehensive "program of life". Throughout his book, Noble turns that view around with a different and far more accurate metaphor, presenting the genome as a database from which the organism can select in order to call upon an elegant modularity of gene expression in a bewildering display of inventiveness of response to environmental and physiological conditions.

Along the way, the author uses a series of music-related analogies to extend his metaphor and piece together the various fragments of his argument into a coherent look at the biology of the organism as a fully functioning system, operating on and at many levels. He shows that far from the established view where the arrows of explanation all point downwards to the lower, ever more fundamental elements of cellular physiology (ending up ultimately at DNA as the primary explanatory element) there exists in reality a complex system of feedback pathways which enable the organism to act upon its own genetic material, altering the way that each gene is expressed in combination with others as a consequence of their whereabouts within the organism, or the conditions to which the organism may be subjected. Within this systems view of biological functioning, the complex pathways of interaction become the primary explanatory elements, rather than any of the physical components themselves.

This single insight provides several additional mechanisms for the operation of evolution through natural selection over and above the simplistic one of random gene mutation which is held in such high regard by today's neo-Darwinists, and reopens the door to the long-ridiculed notion of so-called Lamarckian inheritance of acquired characteristics. It also calls into question the wisdom of, for instance, neurologists seeking the physical location of "the self" within the prescient organism; within Noble's view of things, such concepts as "the self" cease to have any likelihood of an actual physical presence (as separate, identifiable entities within the organism) but instead become emergent functional properties of a level of operation of the biological system itself.

It should be clear by now that this book presents serious challenges to a great deal of current biological dogma and there will be many readers for whom this book is an eye-opener. It is an easy and entertaining read for anyone with even a smattering of science and regardless of whether or not you finally come to agree with Denis Noble, you can be sure you'll find what he has to say interesting and enlightening.